(S)-3,5-DHPG: A Review

(S)-3,5-DHPG: a review.

3,5-dihydroxyphenylglycine (3,5-DHPG) was the first agonist shown to be group I metabotropic glutamate receptor selective with its agonist effects residing exclusively in the S-isomer. Some results suggest that (S)-3,5-DHPG may be a partial agonist of mGluR1a and mGluR5a in neurons and astrocytes. It has been reported that (S)-3,5-DHPG can, under certain conditions, interact with NMDA receptors...

S-35 Guidance Information

The Uptake of 35 S into Rat Tissues after Injection of [ 35 S ] Methionine

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Chapter 35- Orthostatic tremor - a review

The term “orthostatic tremor” (OT) was first coined by Heilman in 1984, although an earlier Italian description of the condition was made in 1970 by Pazzaglia and coworkers. OT is considered a rare condition. It is an intriguing movement disorder characterized by debilitating unsteadiness on standing accompanied by a characteristic 13–18-Hz tremor of the legs (Thompson et al., 1986). Symptoms q...

Effect of (S)-3,5-DHPG on learning, exploratory activity and anxiety in rats with experimental hypoxia.

We investigated the effects of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (I mGluRs), on certain behaviors in rats after short-term hypoxia as a model of experimentally induced amnesia. The effect of (S)-3,5-DHPG administered intracerebroventriculary (icv) at doses of 0.01, 0.1 and 1.0 nmol was assessed using behavioral tests: the open field test, the passive ...